aim : the aim of this study is to evaluate the polymorphism in bax gene and its association with some clinical pathology traits in gastric cancer.   background : gastric cancer is considered as the fourth most common cancer in the north and northwest of iran. bcl2 family has a key role in regulation of apoptosis, and any changes in the expression of bcl2 lead to cancer. patients and methods : b...

global cerebral ischemia (gci) and reperfusion induced apoptosis that lead to cell injury and death. the bax and bcl-2 are pro-apoptotic and anti-apoptotic genes, respectively. these genes belong to the b-cell lymphoma-2 (bcl-2) family.in this study; we assessed the effect of pentoxifylline drug on bax/bcl2 gene dosage expression changes following   ischemic reperfusion injury in kidney. in thi...

ischemia reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. ischemia reperfusion induces cell death and endemic reaction that is one of the most important clinical problems with acute renal failure and renal transplantation. in this study, the effect of pentoxifylline on rat kidney function and cell injury followi...

ataxia telangiectasia (at) is an autosomal recessive multi-system disorder, characterized by variable immunodeficiency, progressive neurodegeneration, occulocutaneous telangiectasia, and increased susceptibility to malignancies. this study was designed to study the role of pro-apoptotic bak, bax, nbk/bik genes in a group of patients with at to elucidate the possible role of these genes in progr...

Introduction: The increasing use of electromagnetic field generators in our daily life in one hand and on contradictory reports on the effects of their waves on public health on the other hand encourages scientists to do more and more research work in this field. One of the most important topics is the study of gene defect due to microwave radiation. Materials and Met...

objective: breast cancer is the second leading cause of cancer death in women. cisplatin is a traditional cancer drug commonly used in chemotherapy for killing cancer cells. modulation at the mrna levels of apoptotic related genes often correlate with the sensitivity of various types of cancer cells to chemotherapeutic agents. nanoparticulate drug delivery systems are being developed to effecti...

introduction: ghrelin is an endogenous peptide that has diverse functions in the body. one of the newly recognized roles of this peptide is its antiapoptotic effect. however, this function has not been investigated in normobaric hypoxia- induced apoptosis in body organs. this study will examine the effect of ghrelin treatment on bax-bcl-2 gene expression in the kidney of chronic hypoxic rats. m...